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Article

Dominant-negative VDAC1 mutants reveal oligomeric VDAC1 to be the active unit in mitochondria-mediated apoptosis.

The Biochemical journal - 1 Jul 2010

Mader Asaf, Abu-Hamad Salah, Arbel Nir, Gutiérrez-Aguilar Manuel, Gutierr-Asuilar Manuel, Shoshan-Barmatz Varda

Abstract excerpt

Mitochondria play a central role in the intrinsic pathway of apoptosis. Oligomerization of the mitochondrial protein VDAC1 (voltage-dependent anion channel 1) has been proposed to play a role in apoptosis in various studies. In the present study, we have generated dimeric fusion proteins consisting of tandem-linked wild-type and RuR (Ruthenium Red)-insensitive mutant VDAC1 monomers and studied the capacity of RuR...

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Source

Identifiers

PMID: 20420578
DOI: 10.1042/BJ20091338

Genes

VDAC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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