Article
Cardiac disease due to random mitochondrial DNA mutations is prevented by cyclosporin A.
Biochemical and biophysical research communications - 9 Jul 2004
Mott J L, Zhang D, Freeman J C, Mikolajczak P, Chang S W, Zassenhaus H P
Abstract excerpt
Mice expressing an error-prone mitochondrial DNA polymerase rapidly accumulate random mutations in mitochondrial DNA. Expression of the transgene in the heart leads to dilated cardiomyopathy accompanied by a wave of apoptosis in cardiomyocytes, and a vigorous and persistent protective response, including upregulation of the anti-apoptotic protein, Bcl-2. To investigate the role of the mitochondrial permeability...
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