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Article

Comparison of ultra-conserved elements in drosophilids and vertebrates.

PloS one - 1 Jan 2013

Makunin Igor V, Shloma Viktor V, Stephen Stuart J, Pheasant Michael, Belyakin Stepan N

Abstract excerpt

Metazoan genomes contain many ultra-conserved elements (UCEs), long sequences identical between distant species. In this study we identified UCEs in drosophilid and vertebrate species with a similar level of phylogenetic divergence measured at protein-coding regions, and demonstrated that both the length and number of UCEs are larger in vertebrates. The proportion of non-exonic UCEs declines in distant...

Topics

Animals
Base Sequence
Conserved Sequence
DNA Transposable Elements
DNA, Intergenic
Drosophilidae
Genome, Insect
Humans
Mutagenesis, Insertional
Phenotype
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Regulatory Sequences, Nucleic Acid

Species Specificity

Synteny

Transcription Initiation Site

Vertebrates

Source

Open in PubMed Open full text

Identifiers

PMID: 24349264
DOI: 10.1371/journal.pone.0082362
PMCID: PMC3862641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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