Article
Multiple transcription factor codes activate epidermal wound-response genes in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2009
Pearson Joseph C, Juarez Michelle T, Kim Myungjin, Drivenes Øyvind, McGinnis William
Abstract excerpt
Wounds in Drosophila and mouse embryos induce similar genetic pathways to repair epidermal barriers. However, the transcription factors that transduce wound signals to repair epidermal barriers are largely unknown. We characterize the transcriptional regulatory enhancers of 4 genes-Ddc, ple, msn, and kkv-that are rapidly activated in epidermal cells surrounding wounds in late Drosophila embryos and early larvae....
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