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Article

Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study.

Pharmacogenetics and genomics - 1 Dec 2011

Elens Laure, Becker Matthijs L, Haufroid Vincent, Hofman Albert, Visser Loes E, Uitterlinden André G, Stricker Bruno Ch, van Schaik Ron H N

Abstract excerpt

OBJECTIVES: CYP3A4 is involved in the oxidative metabolism of many drugs and xenobiotics including the HMG-CoA reductase inhibitor simvastatin. The objective of this study was to investigate whether a new CYP3A4 functional single nucleotide polymorphism (SNP) in intron 6 (CYP3A4*22) modifies the effect of simvastatin on total cholesterol (TOTc) or LDL cholesterol (LDLc) reduction in a population-based cohort...

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PMID: 21946898
DOI: 10.1097/FPC.0b013e32834c6edb

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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