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Article

Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 interval.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2009

Panchanathan Ravichandran, Shen Hui, Bupp Melanie Gubbels, Gould Karen A, Choubey Divaker

Abstract excerpt

Increased expression of IFN-inducible Ifi202 gene in certain strains of female mice is associated with susceptibility to systemic lupus erythematosus (SLE). Although, the development of SLE is known to have a strong sex bias, the molecular mechanisms remain unknown. Here we report that in vivo treatment of orchiectomized (NZB x NZW)F(1) male mice with the female sex hormone 17beta-estradiol significantly...

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Identifiers

PMID: 19890043
DOI: 10.4049/jimmunol.0802665
PMCID: PMC2783550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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