Article
Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi.
Proceedings of the National Academy of Sciences of the United States of America - 30 Nov 2010
Chen Jianming, Xie Changchuan, Tian Lili, Hong Lixin, Wu Xiurong, Han Jiahuai
Abstract excerpt
The signaling network of innate immunity in Drosophila is constructed by multiple evolutionarily conserved pathways, including the Toll- or Imd-regulated NF-κB and JNK pathways. The p38 MAPK pathway is evolutionarily conserved in stress responses, but its role in Drosophila host defense is not fully understood. Here we show that the p38 pathway also participates in Drosophila host defense. In comparison with...
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