Article
Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model.
Neuroscience - 10 Aug 2007
Kohda K, Harada K, Kato K, Hoshino A, Motohashi J, Yamaji T, Morinobu S, Matsuoka N, Kato N
Abstract excerpt
Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experience, and presents with characteristic symptoms, such as intrusive memories, a state of hyperarousal, and avoidance, that endure for years. Single-prolonged stress (SPS) is one of the animal models proposed for PTSD. Rats exposed to SPS showed enhanced inhibition of the hypothalamo-pituitary-adrenal (HPA) axis,...
Topics
- Amygdala
- Animals
- Anxiety Disorders
- Avoidance Learning
- Cell Death
- Corticosterone
- Disease Models, Animal
- Fear
- Hippocampus
- Hypothalamo-Hypophyseal System
- Long-Term Potentiation
- Male
- Memory
- Memory Disorders