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Telomeres and telomerase in cancer

3 Nov 2009

Abstract excerpt

Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation. These somatic events commandeer many signaling pathways that cooperate to endow aspiring cancer cells with a full range of biological capabilities needed to grow, disseminate and ultimately kill its host. Cancer genomes are highly rearranged and are characterized by complex translocations and regional...

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PMID: 19887512
DOI: 10.1093/carcin/bgp268

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