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The Role of Telomere Biology in Cancer

30 Aug 2012

Abstract excerpt

Telomere biology plays a critical and complex role in the initiation and progression of cancer. Although telomere dysfunction resulting from replicative attrition constrains tumor growth by engaging DNA-damage signaling pathways, it can also promote tumorigenesis by causing oncogenic chromosomal rearrangements. Expression of the telomerase enzyme enables telomere-length homeostasis and allows tumor cells to...

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PMID: 22934675
DOI: 10.1146/annurev-pathol-020712-164030

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