Telomeres and Aging

doi:10.1152/physrev.00026.2007

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Article

Telomeres and Aging

1 Apr 2008

Abstract excerpt

Telomeres play a central role in cell fate and aging by adjusting the cellular response to stress and growth stimulation on the basis of previous cell divisions and DNA damage. At least a few hundred nucleotides of telomere repeats must "cap" each chromosome end to avoid activation of DNA repair pathways. Repair of critically short or "uncapped" telomeres by telomerase or recombination is limited in most somatic...

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Identifiers

PMID: 18391173
DOI: 10.1152/physrev.00026.2007

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