Article
Conditioned Medium From Reactive Astrocytes Inhibits Proliferation, Resistance, and Migration of p53-Mutant Glioblastoma Spheroid Through GLI-1 Downregulation.
Journal of cellular biochemistry - 1 Sept 2024
Ribeiro Jessica Honorato, Villarinho Nícolas Jones, Fernandes Priscila Valverde, Spohr Tania Cristina Leite de Sampaio E, Lopes Giselle Pinto de Faria
Abstract excerpt
Glioblastoma (GBM) aggressiveness is partly driven by the reactivation of signaling pathways such as Sonic hedgehog (SHH) and the interaction with its microenvironment. SHH pathway activation is one of the phenomena behind the glial transformation in response to tumor growth. The reactivation of the SHH signaling cascade during GBM-astrocyte interaction is highly relevant to understanding the mechanisms used by...
Topics
- Humans
- Zinc Finger Protein GLI1
- Glioblastoma
- Astrocytes
- Culture Media, Conditioned
- Cell Proliferation
- Cell Movement
- Tumor Suppressor Protein p53
- Spheroids, Cellular
- Hedgehog Proteins
- Down-Regulation
- Cell Line, Tumor