Article
Functional duality of astrocytes in myelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Sept 2011
Nash Besma, Thomson Christine E, Linington Christopher, Arthur Ariel T, McClure John D, McBride Martin W, Barnett Susan C
Abstract excerpt
Astrocytes undergo major phenotypic changes in response to injury and disease that directly influence repair in the CNS, but the mechanisms involved are poorly understood. Previously, we have shown that neurosphere-derived rat astrocytes plated on poly-L-lysine (PLL-astrocytes) support myelination in dissociated rat spinal cord cultures (myelinating cultures). It is hypothesized that astrocyte reactivity can...
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