Article
β-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 2012
Yang Chunzhang, Iyer Rajiv R, Yu Albert C H, Yong Raymund L, Park Deric M, Weil Robert J, Ikejiri Barbara, Brady Roscoe O, Lonser Russell R, Zhuang Zhengping
Abstract excerpt
Astrocytes are the most abundant cell of the CNS and demonstrate contact inhibition in which a nonproliferative, nonmotile cellular state is achieved once stable intercellular contacts are formed between mature cells. Cellular injury disrupts these intercellular contacts, causing a loss of contact inhibition and the rapid initiation of healing. Dysregulation of the molecular pathways involved in this process is...
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