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Article

Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2009

Suzuki Junko, Chen Yunn-Yi, Scott Gary K, Devries Sandy, Chin Koei, Benz Christopher C, Waldman Frederic M, Hwang E Shelley

Abstract excerpt

PURPOSE: Excess histone deacetylase (HDAC) activity can induce hypoacetylation of histone and nonhistone protein substrates, altering gene expression patterns and cell behavior potentially associated with malignant transformation. However, HDAC expression and protein acetylation have not been studied in the context of breast cancer progression. EXPERIMENTAL DESIGN: We assessed expression levels of acetylated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19383825
DOI: 10.1158/1078-0432.CCR-08-2319
PMCID: PMC3746548

Genes

HDAC1
HDAC2
HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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