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Article

Histone deacetylase inhibitors induce epithelial-to-mesenchymal transition in prostate cancer cells.

PloS one - 1 Jan 2012

Kong Dejuan, Ahmad Aamir, Bao Bin, Li Yiwei, Banerjee Sanjeev, Sarkar Fazlul H

Abstract excerpt

Clinical experience of histone deacetylase inhibitors (HDACIs) in patients with solid tumors has been disappointing; however, the molecular mechanism of treatment failure is not known. Therefore, we sought to investigate the molecular mechanism of treatment failure of HDACIs in the present study. We found that HDACIs Trichostatin A (TSA) and Suberoylanilide hydroxamic acid (SAHA) could induce...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23024790
DOI: 10.1371/journal.pone.0045045
PMCID: PMC3443231

Genes

MET
ZEB1
ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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