Article
Alterations of global histone H4K20 methylation during prostate carcinogenesis.
BMC urology - 13 Mar 2012
Behbahani Turang E, Kahl Philip, von der Gathen Johannes, Heukamp Lukas C, Baumann Claudia, Gütgemann Ines, Walter Bernhard, Hofstädter Ferdinand, Bastian Patrick J, von Ruecker Alexander, Müller Stefan C, Rogenhofer Sebastian, Ellinger Jörg
Abstract excerpt
BACKGROUND: Global histone modifications have been implicated in the progression of various tumour entities. Our study was designed to assess global methylation levels of histone 4 lysine 20 (H4K20me1-3) at different stages of prostate cancer (PCA) carcinogenesis. METHODS: Global H4K20 methylation levels were evaluated using a tissue microarray in patients with clinically localized PCA (n = 113), non-malignant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.