Article
Virulence, inflammatory potential, and adaptive immunity induced by Shigella flexneri msbB mutants.
Infection and immunity - 1 Jan 2010
Ranallo Ryan T, Kaminski Robert W, George Tonia, Kordis Alexis A, Chen Qing, Szabo Kathleen, Venkatesan Malabi M
Abstract excerpt
The ability of genetically detoxified lipopolysaccharide (LPS) to stimulate adaptive immune responses is an ongoing area of investigation with significant consequences for the development of safe and effective bacterial vaccines and adjuvants. One approach to genetic detoxification is the deletion of genes whose products modify LPS. The msbB1 and msbB2 genes, which encode late acyltransferases, were deleted in...
Topics
- Adaptive Immunity
- Animals
- Bacterial Proteins
- Cytokines
- Enterobacteriaceae Infections
- Gene Expression Regulation, Bacterial
- HeLa Cells
- Humans
- Inflammation
- Lung
- Lung Diseases
- Mice
- Mutation
- Shigella flexneri