Article
Differential role of lipooligosaccharide of Neisseria meningitidis in virulence and inflammatory response during respiratory infection in mice.
Infection and immunity - 1 Oct 2006
Zarantonelli Maria Leticia, Huerre Michel, Taha Muhamed-Kheir, Alonso Jean-Michel
Abstract excerpt
Meningococcal lipooligosaccharide (LOS) induces a strong proinflammatory response in humans during meningococcal infection. We analyzed the role of LOS in the inflammatory response and virulence during the early infectious process in a mouse model of meningococcal respiratory challenge. An lpxA mutant strain (serogroup B) devoid of LOS (strain Z0204) could not persist in the lungs and did not invade the blood....
Topics
- Animals
- Chemokines
- Cytokines
- Female
- Interleukin-1beta
- Interleukin-6
- Interleukin-8
- Lipopolysaccharides
- Lung
- Meningococcal Infections
- Mice
- Mice, Inbred BALB C
- Mutation
- Neisseria meningitidis
- Pneumonia, Bacterial