Back to search

Article

A genetic interaction screen in <i>Streptococcus pneumoniae</i> identifies functionally redundant vaccine candidate proteins CbpC and CbpJ

2021-04-09

Abstract excerpt

<h4>ABSTRACT</h4> Streptococcus pneumoniae is a Gram-positive bacterium that asymptomatically colonizes the nasopharynx and can disseminate to sterile sites resulting in pneumococcal diseases such as pneumonia, otitis media, bacteremia, and meningitis. Due to increased incidence of invasive disease caused by serotypes that are not included in available polysaccharide vaccines, there is a need for a broadly protec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
95b9006e-aa5d-52e3-8506-d920f6fbb3f0
DOI
10.1101/2021.04.07.438901
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A genetic interaction screen in <i>Streptococcus pneumoniae</i> identifies functionally redundant vaccine candidate proteins CbpC and CbpJDOI 10.1101/2021.04.07.438901
Analysis of Structure and Function of Putative Surface-Exposed Proteins Encoded in the<i>Streptococcus pneumoniae</i>Genome: A Bioinformatics-Based Approach to Vaccine and Drug DesignSemantic proximity
Same, Same, but Different: Molecular Analyses of <i>Streptococcus pneumoniae</i> Immune Evasion Proteins Identifies new Domains and Reveals Structural Differences between PspC and Hic VariantsSemantic proximity
Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine TargetsSemantic proximity
New adhesin functions of surface-exposed pneumococcal proteinsSemantic proximity
Use of a Whole Genome Approach To Identify Vaccine Molecules Affording Protection against Streptococcus pneumoniae InfectionSemantic proximity
Molecular analyses identifies new domains and structural differences among Streptococcus pneumoniae immune evasion proteins PspC and Hic.Semantic proximity
Two DHH Subfamily 1 Proteins Contribute to Pneumococcal Virulence and Confer Protection against Pneumococcal DiseaseSemantic proximity
Versatility of pneumococcal surface proteinsSemantic proximity
Capsule and PspA Cooperatively Confer Resistance of <i>Streptococcus pneumoniae</i> to the Human defensin HNP-1Semantic proximity
The choline-binding proteins PspA, PspC and LytA of <i>Streptococcus pneumoniae</i> and their role on host cellular adhesion and damageSemantic proximity
Molecular pathogenesis of pneumococcal pneumoniaSemantic proximity
Virulence factors in pneumococcal respiratory pathogenesis.Semantic proximity
Select a neighboring publication to make it the new centre.