Article

Capsule and PspA Cooperatively Confer Resistance of <i>Streptococcus pneumoniae</i> to the Human defensin HNP-1

2025-09-29

Abstract excerpt

<h4>ABSTRACT</h4> Streptococcus pneumoniae resists host defenses through multiple virulence factors, yet their combined influence on the action of antimicrobial peptides remains unclear. We examined the role of Pneumococcal surface protein A (PspA) and the polysaccharide capsule in modulating susceptibility to the human defensin HNP-1. PspA-deficient strains of two different genetic backgrounds displayed increase...

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Literature Corpus work: 024358a5-99d8-5639-b29f-f1f387ac1e0a
DOI: 10.1101/2025.09.29.679143

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