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PspC, a Pneumococcal Surface Protein, Binds Human Factor H

1 May 2001

Abstract excerpt

PspC was found to bind human complement factor H (FH) by Western blot analysis of D39 (pspC(+)) and an isogenic mutant TRE108 (pspC). We confirmed that PspA does not bind FH, while purified PspC binds FH very strongly. The binding of FH to exponentially growing pneumococci varied among different isolates when analyzed by fluorescence activated cell sorting analysis.

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PMID: 11292770
DOI: 10.1128/iai.69.5.3435-3437.2001

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