Article
A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia.
Infection and immunity - 1 Jan 2010
Ouma Collins, Keller Christopher C, Davenport Gregory C, Were Tom, Konah Stephen, Otieno Michael F, Hittner James B, Vulule John M, Martinson Jeremy, Ong'echa John M, Ferrell Robert E, Perkins Douglas J
Abstract excerpt
Plasmodium falciparum malaria is a leading global cause of infectious disease burden. In areas in which P. falciparum transmission is holoendemic, such as western Kenya, severe malarial anemia (SMA) results in high rates of pediatric morbidity and mortality. Although the pathophysiological basis of SMA is multifactorial, we recently discovered that suppression of unexplored hematopoietic growth factors that...
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