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Article

The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone.

Peptides - 1 Jan 2010

Glier Melissa B, Pissios Pavlos, Babich Sandra L, Macdonald Marcia L E, Hayden Michael R, Maratos-Flier Eleftheria, Gibson William T

Abstract excerpt

We propose that deletion of pro-melanin-concentrating hormone (pMCH) would increase energy expenditure and further improve glucose tolerance in mice lacking stearoyl-coA desaturase-1 (SCD1). To test our hypothesis, we bred and metabolically challenged Pmch-/-; Scd1-/- double-knockout mice, with comparison to Pmch-/- mice; Scd1-/- mice and C57Bl/6J controls. Deletion of both Pmch and Scd1 increased both food...

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Identifiers

PMID: 19883709
DOI: 10.1016/j.peptides.2009.10.018
PMCID: PMC4096855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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