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Article

MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance.

Diabetes - 1 Feb 2006

Jeon Justin Y, Bradley Richard L, Kokkotou Efi G, Marino Francis E, Wang Xiaomei, Pissios Pavlos, Maratos-Flier Eleftheria

Abstract excerpt

Ablation of the hypothalamic peptide, melanin-concentrating hormone (MCH), leads to a lean phenotype and resistance to diet-induced obesity. Observation of MCH(-/-) mice at older ages suggested that these effects persist in mice >1 year old. Leanness secondary to caloric restriction is known to be associated with improved glucose tolerance as well as an overall increase in life span. Because the MCH(-/-) model...

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Identifiers

PMID: 16443777
DOI: 10.2337/diabetes.55.02.06.db05-0203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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