Article
Disruption of the mGsta4 gene increases life span of C57BL mice.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jan 2010
Singh Sharda P, Niemczyk Maciej, Saini Deepti, Sadovov Vladimir, Zimniak Ludwika, Zimniak Piotr
Abstract excerpt
The lipid peroxidation product 4-hydroxynonenal (4-HNE) forms as a consequence of oxidative stress. By electrophilic attack on biological macromolecules, 4-HNE mediates signaling or may cause toxicity. A major route of 4-HNE disposal is via glutathione conjugation, in the mouse catalyzed primarily by glutathione transferase mGSTA4-4. Unexpectedly, mGsta4-null mice, in which 4-HNE detoxification is impaired, have...
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