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Article

The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis.

PloS one - 1 Jan 2012

Fan Xingjun, Liu Xiaoqin, Hao Shuyu, Wang Benlian, Robinson Michael L, Monnier Vincent M

Abstract excerpt

Age-related nuclear cataracts are associated with progressive post-synthetic modifications of crystallins from various physical chemical and metabolic insults, of which oxidative stress is a major factor. The latter is normally suppressed by high concentrations of glutathione (GSH), which however are very low in the nucleus of the old lens. Here we generated a mouse model of oxidant stress by knocking out...

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Identifiers

PMID: 23226398
DOI: 10.1371/journal.pone.0050832
PMCID: PMC3511334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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