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Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes.

Human immunology - 1 May 2007

Asano Katsuaki, Ikegami Hiroshi, Fujisawa Tomomi, Nishino Masanori, Nojima Koji, Kawabata Yumiko, Noso Shinsuke, Hiromine Yoshihisa, Fukai Aya, Ogihara Toshio

Abstract excerpt

A recent study in the nonobese diabetic (NOD) mouse demonstrated the involvement of interleukin (IL)-21 in the pathogenesis of type 1 diabetes. A strong susceptibility locus, Idd3, has also been mapped to the interval containing the murine gene for IL-21 (Il21), making Il21 and the human orthologue IL21 a functional and positional candidate gene for type 1 diabetes. To investigate the contribution of the human...

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PMID: 17462506
DOI: 10.1016/j.humimm.2007.01.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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