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Article

Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling

31 Oct 2009

Abstract excerpt

Th cell differentiation is precisely regulated by thousands of genes at different stages. In the present study, we demonstrate that Dec2, a transcription factor belonging to the bHLH (basic helix-loop-helix) superfamily, is progressively induced during the course of Th2 differentiation, especially at the late stage. The up-regulated Dec2 can strongly promote Th2 development under Th2-inducing conditions, as...

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PMID: 19880450
DOI: 10.4049/jimmunol.0900975

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