Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PU.1 expression delineates heterogeneity in primary Th2 cells.

Immunity - 1 Jun 2005

Chang Hua-Chen, Zhang Shangming, Thieu Vivian T, Slee Roger B, Bruns Heather A, Laribee R Nicholas, Klemsz Michael J, Kaplan Mark H

Abstract excerpt

Primary T helper 2 cells are heterogeneous, expressing subsets of cytokines at varying levels. Mechanisms controlling this spectrum of phenotypes are still unclear. The ETS family transcription factor PU.1 is expressed in Th2 but not Th1 cells. Th2 cytokine production is decreased in cultures transduced with a PU.1-expressing retrovirus and increased in Th2 cells following RNAi that decreases PU.1 expression. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to GATA3 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to Mice, Inbred BALB C

Share to Retroviridae

Share to RNA Interference

Share to Th1 Cells

Share to Th2 Cells

Source

Identifiers

PMID: 15963784
DOI: 10.1016/j.immuni.2005.03.016

Genes

CCL22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PU.1 expression delineates heterogeneity in primary Th2 cells.PMID 15963784Read ↗

TH2 cell development and functionSemantic proximity Read ↗

Molecular Mechanisms RegulatinG Th1 Immune ResponsesSemantic proximity Read ↗

A transcription factor PU.1 is critical for Ccl22 gene expression in dendritic cells and macrophagesSemantic proximity Read ↗

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammationSemantic proximity Read ↗

Multiple levels of regulation of Th2 cytokine gene expression.Semantic proximity Read ↗

PU.1, a shared transcriptional regulator of lymphoid and myeloid cell fates.Semantic proximity Read ↗

Surprising new roles for PU.1 in the adaptive immune response.Semantic proximity Read ↗

GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factorsSemantic proximity Read ↗

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineagesSemantic proximity Read ↗

Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease.Semantic proximity Read ↗

Cytokine secretion phenotypes of TH cells: how many subsets, how much regulation?Semantic proximity Read ↗

Distinct gene expression profiles of human type 1 and type 2 T helper cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.