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Article

Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells.

Clinical immunology (Orlando, Fla.) - 1 Feb 2014

Ko Myoung Seok, Kim Hyo Jeong, Kim Hong Kyung, Yoon Nal Ae, Lee Unn Hwa, Lee Sang Chul, Chung Dae Kyun, Lee Byung Ju, Suh Jae Hee, Cho Wha Ja, Park Jeong Woo

Abstract excerpt

Developmentally regulated GTP-binding protein 2 (DRG2) represents a novel subclass of GTP-binding proteins. We here report that transgenic overexpression of DRG2 in mice ameliorates experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The protective effect of DRG2 in EAE was mediated by the inhibition of the development of T(H)17 cells. DRG2 enhanced the activity of PPARγ,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24463315
DOI: 10.1016/j.clim.2013.12.004

Genes

DRG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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