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Article

Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers.

Acta psychiatrica Scandinavica - 1 Feb 2018

Polimanti R, Kaufman J, Zhao H, Kranzler H R, Ursano R J, Kessler R C, Stein M B, Gelernter J

Abstract excerpt

OBJECTIVE: To investigate whether trauma exposure moderates the genetic correlation between substance use disorders and psychiatric disorders, we tested whether trauma exposure modifies the association of genetic risks for mental disorders with alcohol misuse and nicotine dependence (ND) symptoms. METHODS: High-resolution polygenic risk scores (PRSs) were calculated for 10 732 US Army soldiers (8346...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29230810
DOI: 10.1111/acps.12843
PMCID: PMC6110087

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