Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.

doi:10.1007/BF03195699

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Article

Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.

Journal of applied genetics - 1 Jan 2009

Nowak I, Malinowski A, Tchorzewski H, Barcz E, Wilczynski J R, Grybos M, Kurpisz M, Luszczek W, Banasik M, Reszczynska-Slezak D, Majorczyk E, Wisniewski A, Senitzer D, Yao Sun J, Kusnierczyk P

Abstract excerpt

Natural killer (NK) cells are the most abundant lymphocyte population in the decidua. These cells express killer immunoglobulin-like receptors (KIRs), which upon recognition of HLA class I molecules on trophoblasts may either stimulate NK cells (activating KIRs) or inhibit them (inhibitory KIRs) to produce soluble factors necessary for the maintenance of pregnancy. KIR genes exhibit extensive haplotype...

Topics

Abortion, Habitual
Abortion, Spontaneous
Adult
Aged
Autoantibodies
Case-Control Studies
Female
Gene Frequency
Genotype
Humans
Killer Cells, Natural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Poland

Pregnancy

Receptors, KIR

Young Adult

Source

Open in PubMed

Identifiers

PMID: 19875891
DOI: 10.1007/BF03195699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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