Article
Comprehensive analysis of HLA-G: implications for recurrent spontaneous abortion.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Apr 2010
Berger Dara S, Hogge W Allen, Barmada M Michael, Ferrell Robert E
Abstract excerpt
Miscarriage is one of the most common pregnancy complications. Recurrent spontaneous abortion is defined as 2 or more pregnancy losses and may be associated with genetic variation. Human leukocyte antigen-G (HLA-G) is a ligand for natural killer (NK) cell receptors and has the ability to block NK cell activity, which if not blocked can potentially harm a fetus. Consequently a deletion or mutation of the HLA-G...
Topics
- Abortion, Spontaneous
- Adult
- Exons
- Female
- HLA Antigens
- HLA-G Antigens
- Haplotypes
- Histocompatibility Antigens Class I
- Humans
- INDEL Mutation
- Linkage Disequilibrium