Article
Detecting signatures of selection from DNA sequences using Datamonkey.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Poon Art F Y, Frost Simon D W, Pond Sergei L Kosakovsky
Abstract excerpt
Natural selection is a fundamental process affecting all evolving populations. In the simplest case, positive selection increases the frequency of alleles that confer a fitness advantage relative to the rest of the population, or increases its genetic diversity, and negative selection removes those alleles that are deleterious. Codon-based models of molecular evolution are able to infer signatures of selection...
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