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Article

Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function.

The Journal of biological chemistry - 26 Mar 2004

Herr Deron R, Fyrst Henrik, Creason Michael B, Phan Van H, Saba Julie D, Harris Greg L

Abstract excerpt

Sphingosine kinase is a highly conserved enzyme that catalyzes the synthesis of sphingosine 1-phosphate and reduces cellular levels of sphingosine and ceramide. Although ceramide is pro-apoptotic and sphingosine is generally growth-inhibitory, sphingosine 1-phosphate signaling promotes cell proliferation, survival, and migration. Sphingosine kinase is thus in a strategic position to regulate important cell fate...

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Identifiers

PMID: 14722126
DOI: 10.1074/jbc.M310647200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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