Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF.

Journal of neurochemistry - 1 Jan 2010

Ali Fahad R, Vasiliou Sylvia A, Haddley Kate, Paredes Ursula M, Roberts Julian C, Miyajima Fabio, Klenova Elena, Bubb Vivien J, Quinn John P

Abstract excerpt

Two distinct variable number tandem repeats (VNTRs) within the human serotonin transporter gene (SLC6A4) have been implicated as predisposing factors for CNS disorders. The linked polymorphic region in the 5'-promoter exists as short (s) and long (l) alleles of a 22 or 23 bp elements. The second within intron 2 (Stin2) exists as three variants containing 9, 10 or 12 copies of a 16 or 17 bp element. These VNTRs,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCCTC-Binding Factor
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Combinatorial Chemistry Techniques

Share to Minisatellite Repeats

Share to Rats, Wistar

Share to Repressor Proteins

Share to Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19860858
DOI: 10.1111/j.1471-4159.2009.06453.x
PMCID: PMC2848977

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF.PMID 19860858Read ↗

Polymorphic DNA repeats in the human serotonin transporter gene locus, predisposing to behavioural disorders, emerge as functional regulators of gene expressionSemantic proximity Read ↗

YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders.Semantic proximity Read ↗

The serotonin transporter intronic VNTR enhancer correlated with a predisposition to affective disorders has distinct regulatory elements within the domain based on the primary DNA sequence of the repeat unit.Semantic proximity Read ↗

An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells.Semantic proximity Read ↗

Simultaneous genotyping of multiple polymorphisms in human serotonin transporter gene and detection of novel allelic variants.Semantic proximity Read ↗

Allele-specific transcriptional activity of the variable number of tandem repeats in 5' region of the DRD4 gene is stimulus specific in human neuronal cells.Semantic proximity Read ↗

Molecular genetics of monoamine transporters: relevance to brain disorders.Semantic proximity Read ↗

Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression.Semantic proximity Read ↗

Modified structure of the human serotonin transporter promoter.Semantic proximity Read ↗

The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neuronsSemantic proximity Read ↗

ITGB3 shows genetic and expression interaction with SLC6A4.Semantic proximity Read ↗

A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.