Article
A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder.
Proceedings of the National Academy of Sciences of the United States of America - 12 Dec 2006
Kim Chun-Hyung, Hahn Maureen K, Joung Yoosook, Anderson Susan L, Steele Angela H, Mazei-Robinson Michelle S, Gizer Ian, Teicher Martin H, Cohen Bruce M, Robertson David, Waldman Irwin D, Blakely Randy D, Kim Kwang-Soo
Abstract excerpt
The norepinephrine transporter critically regulates both neurotransmission and homeostasis of norepinephrine in the nervous system. In this study, we report a previously uncharacterized and common A/T polymorphism at -3081 upstream of the transcription initiation site of the human norepinephrine transporter gene [solute carrier family 6, member 2 (SLC6A2)]. Using both homologous and heterologous promoter-reporter...
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