Article
Molecular genetics of monoamine transporters: relevance to brain disorders.
Neurochemical research - 1 Apr 2008
Haddley K, Vasiliou A S, Ali F R, Paredes U M, Bubb V J, Quinn J P
Abstract excerpt
We have demonstrated in both the human serotonin transporter gene (5HTT) and the dopamine transporter gene (DAT1) that specific polymorphic variants termed Variable Number Tandem Repeats (VNTRs), which correlate with predisposition to a number of neurological and psychiatric disorders, act as transcriptional regulatory domains. We have demonstrated that these domains can act as both tissue-specific and...
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