Article
Modified structure of the human serotonin transporter promoter.
Molecular psychiatry - 1 Jan 2000
Flattem N L, Blakely R D
Abstract excerpt
Recently, several studies have reported an association between anxiety traits, affective disorders and autism and alleles of a functional promoter polymorphism (5HTT-LPR) in the human serotonin transporter (5HTT, SERT).1-3 The mechanistic basis for allelic differences in transporter transcription are presently unknown. To explore this issue, we cloned the human 5HTT promoter region from a PAC genomic library and...
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