Article
Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression.
Biological psychiatry - 1 Jun 2004
Hranilovic Dubravka, Stefulj Jasminka, Schwab Sibylle, Borrmann-Hassenbach Margitta, Albus Margot, Jernej Branimir, Wildenauer Dieter
Abstract excerpt
BACKGROUND: Two polymorphic regions of serotonin transporter (5-HTT) gene: a 44 base pair (bp) insertion/deletion in the promoter region (5-HTTLPR) and a 17 bp variable number of tandem repeats in second intron (VNTR-2), seem to modulate the gene's transcription in allele-dependent manner. METHODS: We have earlier demonstrated association with 5-HTT gene in families multiply affected by schizophrenia. Here, we...
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