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Article

YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Jun 2004

Klenova Elena, Scott Alison C, Roberts Julian, Shamsuddin Shaharum, Lovejoy Elizabeth A, Bergmann Stephan, Bubb Vivien J, Royer Hans-Dieter, Quinn John P

Abstract excerpt

The serotonin transporter (5-HTT) gene contains a variable number tandem repeat (VNTR) domain within intron 2 that is often associated with a number of neurological conditions, including affective disorders. The implications of this polymorphism are not yet understood, however, we have previously demonstrated that the 5-HTT VNTR is a transcriptional regulatory domain, and the allelic variation supports...

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Source

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Identifiers

PMID: 15229244
DOI: 10.1523/JNEUROSCI.1150-04.2004
PMCID: PMC6729234

Genes

CTCF
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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