Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin.

Scientific reports - 21 Nov 2019

Malintan Nancy T, Buckingham Steven D, Lomas David A, Sattelle David B

Abstract excerpt

A possible role for calcium signalling in the autosomal dominant form of dementia, familial encephalopathy with neuroserpin inclusion bodies (FENIB), has been proposed, which may point towards a mechanism by which cells could sense and respond to the accumulation of mutant serpin polymers in the endoplasmic reticulum (ER). We therefore explored possible defects in Ca2+-signalling, which may contribute to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha 1-Antitrypsin
Share to Calcium Signaling
Share to CHO Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetulus

Share to Epilepsies, Myoclonic

Share to Heredodegenerative Disorders, Nervous System

Share to Microscopy, Confocal

Share to Optical Imaging

Source

Open in PubMed Open full text

Identifiers

PMID: 31754242
DOI: 10.1038/s41598-019-53535-1
PMCID: PMC6872872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin.PMID 31754242Read ↗

Abnormal intracellular ca(2+)homeostasis and disease.Semantic proximity Read ↗

The PMCA pumps in genetically determined neuronal pathologies.Semantic proximity Read ↗

Intracellular calcium signalling in Alzheimer’s diseaseSemantic proximity Read ↗

The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells.Semantic proximity Read ↗

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.Semantic proximity Read ↗

Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation.Semantic proximity Read ↗

Disorders of calcium ion sensing.Semantic proximity Read ↗

Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake.Semantic proximity Read ↗

Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels.Semantic proximity Read ↗

Cellular Models for the Serpinopathies.Semantic proximity Read ↗

Ca 2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2Semantic proximity Read ↗

Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2+ levels and dynamics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.