Article
Glutathione S transferase deficiency and passive smoking increase childhood asthma.
Thorax - 1 Jul 2004
Kabesch M, Hoefler C, Carr D, Leupold W, Weiland S K, von Mutius E
Abstract excerpt
BACKGROUND: It has been suggested that the genetically determined deficiency of glutathione S transferase (GST) enzymes involved in the detoxification of environmental tobacco smoke (ETS) components may contribute to the development of asthma. METHODS: A large population of German schoolchildren (n = 3054) was genotyped for deficiencies of the GST isoforms M1 and T1. The association between GSTM1 and GSTT1...
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