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Article

Tamoxifen-stimulated growth of breast cancer due to p21 loss

27 Dec 2007

Abstract excerpt

Tamoxifen is widely used for the treatment of hormonally responsive breast cancers. However, some resistant breast cancers develop a growth proliferative response to this drug, as evidenced by tumor regression upon its withdrawal. To elucidate the molecular mediators of this paradox, tissue samples from a patient with tamoxifen-stimulated breast cancer were analyzed. These studies revealed that loss of the...

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Identifiers

PMID: 18162533
DOI: 10.1073/pnas.0710887105

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