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Article

p21 (WAF1/CIP1) Mediates the Growth Response to TGF-b in Human Epithelial Cells

2 Feb 2004

Abstract excerpt

We investigated the mechanism by which cancers evade the growth inhibitory effects of TGF-beta. Using two p21-/- somatically deleted human epithelial cell lines, we find that TGF-beta serves as a growth stimulator rather than a growth suppressor to cells lacking p21. In addition, TGF-beta stimulated p21-/- cells exhibited a mesenchymal phenotype, demonstrated by an upregulation of vimentin and decreased...

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PMID: 14726675
DOI: 10.4161/cbt.3.2.666

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