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Article

Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells

22 Apr 2003

Abstract excerpt

Relative quiescence is a defining characteristic of hematopoietic stem cells. Reasoning that inhibitory tone dominates control of stem cell cycling, we previously showed that mice engineered to be deficient in the cyclin-dependent kinase inhibitor, p21Cip1/Waf1 (p21), have an increased stem cell pool under homeostatic conditions. Since p21 was necessary to maintain stem cell quiescence and its absence sufficient...

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PMID: 12702511
DOI: 10.1182/blood-2002-10-3053

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