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Article

p21Cip1 nullizygosity increases tumor metastasis in irradiated mice.

Cancer research - 15 Jun 2003

Jackson Rosalind J, Engelman Robert W, Coppola Domenico, Cantor Alan B, Wharton Walker, Pledger W Jack

Abstract excerpt

p21(Cip1) is a cyclin-dependent kinase inhibitor whose abundance increases in cells exposed to radiation or other DNA-damaging agents. Such increases activate a G1 checkpoint, which allows time for DNA repair before S phase entry. By inhibiting cell cycle progression, p21(Cip1) potentially suppresses tumorigenesis, and in support, we show that p21(Cip1) heterozygous and nullizygous mice develop more tumors than...

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Identifiers

PMID: 12810620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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p21Cip1 nullizygosity increases tumor metastasis in irradiated mice.PMID 12810620Read ↗

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