Article
In vivo genotoxicity of EMS: statistical assessment of the dose response curves.
Toxicology letters - 12 Nov 2009
Gocke Elmar, Wall Michael
Abstract excerpt
EMS induced micronuclei and lacZ mutations in in vivo studies in mice with a clearly sublinear dose dependency. As reported elsewhere in this issue, NOEL dose values of between 25 mg/kg/day and 80 mg/kg/day were observed for the different endpoints and tissues analysed. Here we show that statisti...
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