Article
In vivo genotoxicity of EMS: statistical assessment of the dose response curves.
Toxicology letters - 12 Nov 2009
Gocke Elmar, Wall Michael
Abstract excerpt
EMS induced micronuclei and lacZ mutations in in vivo studies in mice with a clearly sublinear dose dependency. As reported elsewhere in this issue, NOEL dose values of between 25 mg/kg/day and 80 mg/kg/day were observed for the different endpoints and tissues analysed. Here we show that statistical assessment of the data provides solid support that the induction of mutagenic and clastogenic effects after in vivo...
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