Article
Do dose response thresholds exist for genotoxic alkylating agents?
Mutagenesis - 1 Nov 2005
Jenkins G J S, Doak S H, Johnson G E, Quick E, Waters E M, Parry J M
Abstract excerpt
The demonstration and acceptance of dose response thresholds for genotoxins may have substantial implications for the setting of safe exposure levels. Here we test the hypothesis that direct-acting DNA reactive agents may exhibit thresholded dose responses. We examine the potential mechanisms involved in such thresholded responses, particularly in relation to those of alkylating agents. As alkylating agents are...
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